Six other people were injured in the accident, including Ma'ayan's seven-year-old brother Uri, who suffered a head injury, and his father, Ilya Domnovitch, who is listed in critical condition.
Three other members of the family are in moderate condition.
Ayala Domnovitch, the mother of the family, asked the public to pray for the recovery of herself and the other family members injured:
Ilya Yinon Shraga Ben Baya Yardena
Ayala Molly Bat Nechama
Uri Amidan Ben Ayala Molly
Netta Avraham Ben Ayala Molly
Shachar Yisrael ben Ayala Molly
Gush Etzion Mayor and Chairman of the Yesha Council Shlomo Neeman said: "At the height of Yom Ha'atzmaut (Independence Day) we were given the terrible news about the fatal traffic accident involving a family from Nokdim, Gush Etzion. Unfortunately, the baby of the family Ma'ayan succumbed to his wounds. We will pray for the recovery of the other family members and offer the community of Nokdim a warm embrace."
Yair and Anat Abelson, a married couple who volunteer with United Hatzalah and responded to the accident, said: "This was an accident involving two vehicles. A baby who was in one of the vehicles was declared dead at the scene. Firefighter crews also operated at the scene due to the nature of the accident. We also provided assistance to four moderately to severely injured people."
Magen David Adom stated: "A report was received at MDA's 101 hotline in the Negev region regarding a collision between two vehicles on Highway 40. MDA medics and paramedics provided medical treatment to people with various degrees of injury, including a toddler ... whose death was determined. Four injured people have been evacuated to Soroka Hospital, including two people in serious condition (a man in his 40s with wounds to his limbs, and a six-year-old boy with a head injury) and two people in moderate condition (both women in their 30s with injuries to their limbs)."